• Impotence Herbal Remedy- 5 Natural Health Secrets to Cure Your Erectile Dysfunction

    21 April 2008 (Monday)

    Why are thousands of men choosing an impotence herbal remedy over the colorful synthetic pills to cure erectile dysfunctions? Because they know the sometimes fatal side effects associated with erectile dysfunction pills.

  • Happy Birthday, Viagra!

    03 April 2008 (Thursday)

    It's the drug that raised the profile of medicine in popular culture. It's been hawked by a prominent politician and has been the butt of jokes on late-night TV. It's Viagara, and it's turning 10 today.

  • FDA Warns Consumers Not To Use "Blue Steel" And "Hero" Products

    03 April 2008 (Thursday)

    The U.S. Food and Drug Administration is advising consumers not to purchase or use "Blue Steel" or "Hero" products marketed as dietary supplements throughout the United States because they are considered unapproved drugs and have not been proven to be safe or effective. These products contain undeclared ingredients, which may dangerously affect a person's blood pressure level.

  • Viagra may help men lift their spirits, too

    24 March 2008 (Monday)

    Impotence drugs such as Viagra may do more than help men physically have sex - they may also boost levels of a hormone linked with feelings of love, United States researchers reported on Thursday.

  • Viagra still going strong 10 years on

    23 March 2008 (Sunday)

    Viagra, developed by accident by scientists at Pfizer Laboratories, was first approved for use by the US Food and Drug Administration on March 27, 1998.

Viagra, Sildenafil (generic) News

Impotence Drugs

03 October 2007 (Wednesday)

Erectile dysfunction (ED or (male) impotence) is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis impotence drugs. There are various underlying causes, such as cardiovascular leakage and diabetes, many of which are medically treatable impotence drugs.
The causes of erectile dysfunction may be physiological or psychological impotence drugs. Physiologically, erection is a hydraulic mechanism based upon blood entering and being retained in the penis, and there are various ways in which this can be impeded, most of which are amenable to treatment impotence drugs. Psychological impotence is where erection or penetration fails due to thoughts or feelings (psychological reasons) rather than physical impossibility; this can often be helped impotence drugs. Notably in psychological impotence there is a very strong placebo effect impotence drugs.
Erectile dysfunction, tied closely as it is to cultural notions of potency, success and masculinity, can have devastating psychological consequences including feelings of shame, loss or inadequacy; often unnecessary since in most cases the matter can be helped impotence drugs. There is a strong culture of silence and inability to discuss the matter impotence drugs. In fact around 1 in 10 men will experience recurring impotence problems at some point in their lives impotence drugs.
Folk remedies have long been advocated, with some being advertised widely since the 1930s impotence drugs. The introduction of the first pharmacologically approved remedy for impotence, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, propelled in part by heavy advertising impotence drugs.
The Latin term impotentia coeundi describes simple inability to insert the penis into the vagina impotence drugs. It is now mostly replaced by more precise terms impotence drugs. The study of erectile dysfunction within medicine is covered by andrology, a sub-field within urology impotence drugs.

Overview and symptoms

Erectile dysfunction is characterized by the regular or repeated inability to obtain or maintain an erection impotence drugs. There are several ways that erectile dysfunction is analyzed:

  • Obtaining full erections at some times, such as when asleep (when the mind and psychological issues if any are less present), tends to suggest the physical structures are functionally working impotence drugs. However the opposite case, a lack of nocturnal erections, does not imply the opposite, since a significant proportion of sexually functional men do not routinely get nocturnal erections or wet dreams impotence drugs.
  • Obtaining erections which are either not rigid or full (lazy erection), or are lost more rapidly than would be expected (often before or during penetration), can be a sign of a failure of the mechanism which keeps blood held in the penis, and may signify an underlying clinical condition, often cardiovascular in origin impotence drugs.
  • Other factors leading to erectile dysfunction are diabetes mellitus (causing neuropathy) or hypogonadism (decreased testosterone levels due to disease affecting the testicles or the pituitary gland) impotence drugs.

Erection problems are very common impotence drugs. The Sexual Dysfunction Association estimates that 1 in 10 men in the UK have recurring problems with their erections at some point in their life impotence drugs.

Pathophysiology

Penile erection is managed by two different mechanisms impotence drugs. The first one is the reflex erection, which is achieved by directly touching the penile shaft impotence drugs. The second is the psychogenic erection, which is achieved by erotic or emotional stimuli impotence drugs. The former uses the peripheral nerves and the lower parts of the spinal cord, whereas the latter uses the limbic system of the brain impotence drugs. In both conditions an intact neural system is required for a successful and complete erection impotence drugs. Stimulation of penile shaft by the nervous system leads to the secretion of nitric oxide (NO), which causes the relaxation of smooth muscles of corpora cavernosa (the main erectile tissue of penis), and subsequently penile erection impotence drugs. Additionally, adequate levels of testosterone (produced by the testes) and an intact pituitary gland are required for the development of a healthy male erectile system impotence drugs. As can be understood from the mechanisms of a normal erection, impotence may develop due to hormonal deficiency, disorders of the neural system, lack of adequate penile blood supply or psychological problems impotence drugs. Restriction of blood flow can arise from impaired endothelial function due to the usual causes associated with coronary artery disease, but can also include causation by prolonged exposure to bright light or chronic exposure to high noise levels impotence drugs.
A few causes of impotence may be iatrogenic (medically caused) impotence drugs. Various antihypertensives (medications intended to control high blood pressure) and some drugs that modify central nervous system response may inhibit erection by denying blood supply or by altering nerve activity impotence drugs.
Surgical intervention for a number of different conditions may remove anatomical structures necessary to erection, damage nerves, or impair blood supply impotence drugs.Complete removal of the prostate gland or external beam radiotherapy of the gland are common causes of impotence; both are treatments for advanced prostate cancer impotence drugs. Some studies have shown that male circumcision may result in an increased risk of impotence, while others have found no such effect, and another found the opposite impotence drugs.
Excessive alcohol use has long been recognised as one cause of impotence, leading to the euphemism “brewer”s droop,” or “whiskey dick;” Shakespeare made light of this phenomenon in Macbeth impotence drugs.
A study in 2002 found that ED can also be associated with bicycling impotence drugs. The number of hours on a bike and/or the pressure on the penis from the saddle of an upright bicycle is directly related to erectile dysfunction impotence drugs.

Diagnosis

 

Medical diagnosis

There are no formal tests to diagnose erectile dysfunction impotence drugs. Some blood tests are generally done to exclude underlying disease, such as diabetes, hypogonadism and prolactinoma impotence drugs. Impotence is also related to generally poor physical health, poor dietary habits, obesity, and most specifically cardiovascular disease such as coronary artery disease and peripheral vascular disease impotence drugs.
A useful and simple way to distinguish between physiological and psychological impotence is to determine whether the patient ever has an erection impotence drugs. If never, the problem is likely to be physiological; if sometimes (however rarely), it could be physiological or psychological impotence drugs. The current diagnostic and statistical manual of mental diseases (DSM-IV) has included a listing for impotence impotence drugs.

Clinical Tests Used to Diagnose ED

Duplex ultrasound
Duplex ultrasound is used to evaluate blood flow, venous leak, signs of atherosclerosis, and scarring or calcification of erectile tissue impotence drugs. Injecting prostaglandin, a hormone-like stimulator produced in the body, induces erection impotence drugs. Ultrasound is then used to see vascular dilation and measure penile blood pressure impotence drugs. Measurements are compared to those taken when the penis is flaccid impotence drugs.
Penile nerves function
Tests such as the bulbocavernosus reflex test are used to determine if there is sufficient nerve sensation in the penis impotence drugs. The physician squeezes the glans (head) of the penis, which immediately causes the anus to contract if nerve function is normal impotence drugs. A physician measures the latency between squeeze and contraction by observing the anal sphincter or by feeling it with a gloved finger inserted past the anus impotence drugs. Specific nerve tests are used in patients with suspected nerve damage as a result of diabetes or nerve disease impotence drugs.
Nocturnal penile tumescence (NPT)
It is normal for a man to have five to six erections during sleep, especially during rapid eye movement (REM) impotence drugs. Their absence may indicate a problem with nerve function or blood supply in the penis impotence drugs. There are two methods for measuring changes in penile rigidity and circumference during nocturnal erection: snap gauge and strain gauge impotence drugs. (It should be noted that a significant proportion of men who have no sexual dysfunction nonetheless do not have regular nocturnal erections impotence drugs.Thus presence of NPT tends to signify physically functional systems, but absence of NPT may be ambiguous and not rule out either cause impotence drugs.)
Penile biothesiometry
This test uses electromagnetic vibration to evaluate sensitivity and nerve function in the glans and shaft of the penis impotence drugs. A decreased perception of vibration may indicate nerve damage in the pelvic area, which can lead to impotence impotence drugs.
Penile Angiogram
Invasive test - allows visualization of the circulation in the penis and is used during the repair of a priapism impotence drugs.
Dynamic Infusion Cavernosometry
(Abbreviated DICC) technique in which fluid is pumped into the penis at a known rate and pressure impotence drugs. It gives a measurement of the vascular pressure in the corpus cavernosum during an erection impotence drugs. To do this test, a vasodilator like prostaglandin E-1 is injected to measure the rate of infusion required to get a rigid erection and to help find how severe the venous leak is impotence drugs.
Corpus Cavernosometry
Cavernosography measurement of the vascular pressure in the corpus cavernosum impotence drugs. Saline is infused under pressure into the corpus cavernosum with a butterfly needle, and the flow rate needed to maintain an erection indicates the degree of venous leakage impotence drugs. The leaking veins responsible may be visualised by infusing a mixture of saline and x ray contrast medium and performing a cavernosogram impotence drugs.
Digital Subtraction Angiography
In DSA, the images are acquired digitally impotence drugs. The computer creates a mask from lower-contrast x-rays of the same area and digitally isolates the blood vessels (this is done manually through darkroom masking with traditional angiography) impotence drugs.
Magnetic resonance angiography (MRA)
This is similar to magnetic resonance imaging impotence drugs. Magnetic resonance angiography uses magnetic fields and radio waves to provide detailed images of the blood vessels impotence drugs. Doctors may inject a “contrast agent” into the patient”s bloodstream that causes vascular tissues to stand out against other tissues impotence drugs. The contrast agent provides for enhanced information regarding blood supply and vascular anomalies impotence drugs. Aside from the IV used to introduce the contrast material into the bloodstream, magnetic resonance angiography is noninvasive and painless impotence drugs.

 

Treatment

Treatment depends on the cause impotence drugs. Testosterone supplements may be used for cases due to hormonal deficiency impotence drugs. However, the cause is more usually lack of adequate penile blood supply as a result of damage to inner walls of blood vessels impotence drugs. This damage is more frequent in older men, and often associated with disease, in particular diabetes impotence drugs.
Treatments (with the exception of testosterone supplementation, where effective) work on a temporary basis: they enable an erection to be attained and maintained long enough for intercourse, but do not permanently improve the underlying condition impotence drugs. There are different treatments available:

Oral treatment

3 different tablets are currently available from the doctor and these work when there is sexual stimulation impotence drugs. Depending on the treatment, it will need to be taken 20 minutes to 1 hour before sex and the period of time over which it works can vary between 3 hours and up to 36 hours impotence drugs.

Alprostadil

This can be injected into the penis or inserted using a special applicator - usually just before sexual intercourse impotence drugs.

BEFAR

Currently, only commercially available in the Far East, Befar® has shown a clinical efficacy of up to 83% in patients with varying degrees of ED impotence drugs. (6) The cream itself has a onset action of 10-15 minutes and can continue on past 4-hours, (Figure 2) and is favorably comparable to the efficacy of the injectable alprostadil impotence drugs. (3, 19)
Due to Befar’s direct application method (i impotence drugs.e impotence drugs. unlike Viagra®, Befar’s actions are limited to the area of its application), the side effects induced by the application have to date been limited to transient warm and burning sensations impotence drugs.
So instead of using an injectable or intra-urethral pellet, Befar® cream rapidly and effectively promotes the permeation of alprostadil into the active site of the penis impotence drugs. Can be purchased at:

Vacuum pumps

These work by drawing blood into the penis and are also used just before sexual intercourse impotence drugs.

Hormone treatment

It is rare, but some men receive hormones for their erection problem impotence drugs. This does depend on the cause of the problem as well as other factors impotence drugs.

Surgery

Often, as a last resort if other treatments have failed, the most common procedure is prosthetic implants which involves the insertion of artificial rods into the penis impotence drugs.

Counselling

Counselling is often a consideration, both where a psychological cause is suspected or must be ruled out, or to assist in management of any distress impotence drugs.
ED can in many cases be treated by drugs taken orally, injected, or as penile suppositories impotence drugs. These drugs increase the efficacy of NO, which dilates the blood vessels of corpora cavernosa impotence drugs. When oral drugs or suppositories fail, injections into the erectile tissue of the penile shaft are extremely effective but occasionally cause priapism impotence drugs. When pharmacological methods fail, a purpose-designed external vacuum pump can be used to attain erection, with a separate compression ring fitted to the penis to maintain it impotence drugs. These pumps should be distinguished from other “penis pumps” (supplied without compression rings) which, rather than being used for temporary treatment of impotence, are claimed to increase penis length if used frequently, or vibrate as an aid to masturbation impotence drugs.
More drastically, inflatable or rigid penile implants may be fitted surgically impotence drugs. Implants are irreversible and costly impotence drugs.
All these mechanical methods are based on simple principles of hydraulics and mechanics and are quite reliable, but have their disadvantages impotence drugs.
In a few cases there is a vascular problem which can be treated surgically impotence drugs.

Uncontroversial treatments

PDE5 Inhibitors
The cyclic nucleotide phosphodiesterases constitute a group of enzymes that catalyse the hydrolysis of the cyclic nucleotides cyclic AMP and cyclic GMP impotence drugs. They exist in different molecular forms and are unevenly distributed throughout the body impotence drugs. These multiple forms or subtypes of phosphodiesterase were initially isolated from rat brain by Uzunov and Weiss in 1972 and were soon afterwards shown to be selectively inhibited by a variety of drugs in brain and other tissues impotence drugs. The potential for selective phosphodisterase inhibitors to be used as therapeutic agents was predicted as early as 1977 by Weiss and Hait impotence drugs. This prediction has now come to pass in a variety of fields, one of which is in the pharmacological treatment of erectile dysfunction impotence drugs.

One of the forms of phophodiesterase is termed PDE5 impotence drugs. The prescription PDE5 inhibitors sildenafil (Viagra®), vardenafil (Levitra®) and tadalafil (Cialis®) are prescription drugs which are taken orally impotence drugs. They work by blocking the action of PDE5, which causes cGMP to degrade impotence drugs. CGMP specific phosphodiesterase type 5 causes the smooth muscle of the arteries in the penis to relax, allowing the corpus cavernosum to fill with blood impotence drugs.
(Specific devices are mentioned for information only; mention should not be taken as endorsement) impotence drugs.

Dopamine Receptor Agonist
Inflatable implant
Rigid implant
Surgical treatment of certain cases

 

Controversial and unapproved treatments

Naltrexone
Drug used for treating drug addicts can have some success in patients with inhibited sexual desire impotence drugs.
Bremelanotide
The experimental drug bremelanotide (formerly PT-141) does not act on the vascular system like the former compounds but allegedly increases sexual desire and drive in males as well as females impotence drugs. It is applied as a nasal spray impotence drugs. Bremelanotide allegedly works by activating melanocortin receptors in the brain impotence drugs. It is currently in Phase IIb trials impotence drugs.
Melanotan II
Like bremelanotide the experimental drug Melanotan II does not act on the vascular system either but increases libido impotence drugs. Melanotan II works by activating melanocortin receptors in the brain impotence drugs.
hMaxi-K
hMaxi-K is a form of gene therapy using a plasmid vector that expresses the hSlo gene, that encodes the alpha-subunit of the Maxi-K channel impotence drugs. It has undergone phase I safety trials impotence drugs.
Ginseng
A double-blind study appears to show evidence that ginseng is better than placebo: see the ginseng article for more details impotence drugs.
Enzyte
Enzyte is a product that has been advertised by saturation coverage on television channels such as CourtTV impotence drugs. However, the Center for Science in the Public Interest (CSPI) has filed a complaint with the Federal Trade Commission (FTC) about Enzyte for deceptive advertising impotence drugs. It is manufactured by Berkeley Nutritionals, which is alleged to be the subject of an investigation by the Attorney General of Ohio and the defendant in class-action lawsuits impotence drugs.
Enzyte is a supplement that claims to increase the male libido or frequency of erections of the penis impotence drugs. Commercials for Enzyte are shown regularly on television impotence drugs. These commercials feature a man named Bob who never stops smiling, apparently because he had taken Enzyte and improved the size of his sex organs impotence drugs. The commercials are riddled with symbolic phallic imagery, e impotence drugs.g impotence drugs. golf clubs, remarkably tall glasses of iced tea, and a hose spraying barely a trickle of water (carried by someone who doesn”t use Enzyte) impotence drugs.
The effectiveness of Enzyte is in dispute impotence drugs. Some medical professionals in fact advise against taking Enzyte, saying that it can lead to damage impotence drugs. The Center for Science in the Public Interest have urged the Federal Trade Commission to disallow further television advertising for Enzyte due to a lack of proper studies supporting claims impotence drugs. Enzyte maker Berkeley Premium Nutraceuticals, Inc impotence drugs., is currently under a class action lawsuit for false advertising impotence drugs.
Enzyte is said to contain: Tribulus terrestris; Yohimbe Extract; Niacin; Epimedium; Avena sativa; zinc oxide; maca; Muira Pauma; Ginkgo biloba; L-Arginine; Saw Palmetto impotence drugs. Other ingredients: gelatin, rice bran, oat fiber, magnesium stearate, silicon dioxide impotence drugs.
Herbal and other alternative treatments
These are generally ineffective when tested blind, but may be useful for their psychological (placebo) effect: if a good result is expected, any highly praised, and often expensive, treatment can be effective impotence drugs. Reputable drugs can also benefit from the same effect impotence drugs.
Prelox
Prelox is a Proprietary mix/combination of naturally occurring ingredients, L-arginine aspartate and Pycnogenol impotence drugs. In double blind tests carried out by Dr impotence drugs. Steven Lamm at New York University School of Medicine, 81 impotence drugs.1% of men overall judged Prelox to be effective in improving their ability to engage in sexual activity impotence drugs.Prelox® for improvement of erectile function: A review European Bulletin of Drug Research, Volume 11, No impotence drugs. 3, 2003 impotence drugs. Steven Lamm, Frank Schoenlau, Peter Rohdewald Whilst the supplements should be taken daily, the manufacturers claim that it brings the spontaneity back into ones” love life; unlike other products which must be remembered to be taken a fixed time before sexual activity impotence drugs.

 

Other treatment methods

 

Zinc

Zinc is known to help prevent the conversion of testosterone to estradiol, and testosterone is essential for proper erectile function and the synthesis of sperm (testosterone deficiency is a primary contributor in many cases of erectile dysfunction) impotence drugs. Moreover, zinc levels have been found to be significantly reduced in both chronic bacterial prostatitis (CBP) and non-bacterial prostatitis (NBP) impotence drugs. Many doctors and nutritionalists recommend zinc for prostate or erectile problems impotence drugs.
Zinc is best taken in lozenge form, as in tablet form the zinc is difficult to absorb, and can irritate the stomach lining impotence drugs.

History

Dr impotence drugs. John R impotence drugs. Brinkley initiated a boom in male impotence cures in the US in the 1920s and 1930s impotence drugs. His radio programs recommended expensive goat gland implants and “mercurochrome” injections as the path to restored male virility, including operations by surgeon Serge Voronoff impotence drugs. After the Kansas State Medical Board revoked his medical license and the Federal Radio Commission refused to renew his radio license (both in 1930), Brinkley moved his operations just over the Texas border to Mexico where he opened a medical clinic and broadcast advertisements into the US from a border blaster radio station impotence drugs.
Surgeons began providing patients with inflatable penile implants in the 1970s impotence drugs.
Modern drug therapy for ED made a significant advance in 1983 when British physiologist Giles Brindley, Ph impotence drugs.D impotence drugs. dropped his trousers and demonstrated to a shocked American Urological Association audience his phentolamine-induced erection impotence drugs. The drug Brindley injected into his penis was a non-specific vasodilator, an alpha-blocking agent, and the mechanism of action was clearly corporal smooth muscle relaxation impotence drugs. The effect that Brindley discovered established the fundamentals for the later development of specific, safe, orally-effective drug therapies impotence drugs.
Reference: Helgason ÁR, Adolfsson J, Dickman P, Arver S, Fredrikson M, Göthberg M, Steineck G impotence drugs. Sexual desire, erection, orgasm and ejaculatory functions and their importance to elderly Swedish men: A population-based study impotence drugs. Age and Ageing impotence drugs. 1996:25:285-291 impotence drugs.

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  • The Differences Between Viagra, Cialis, and Levitra

    05 October 2007 (Friday)

    Viagra (Sildenafil), also known as “The Blue Pill”, is available in 25mg, 50mg and 100mg pills. Viagra can be taken once per day, between 30 minutes to 4 hours before sexual intercourse.

  • Difference between Viagra vs Generic Viagra

    05 October 2007 (Friday)

    A generic drug must contain the same active ingredients and must be equivalent in strength and dosage to the original brand-name product. While generics and brand-name drugs contain the same active ingredients, the inactive ingredients may be different.